CB-6644 - CAS# 2316817-88-4 BI-98782 Molecular Weight: 484

Molecular Weight: 484

2002 Nov-Dec

Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion

PNRI-299 has no effect on NF-κB transcription (up to 200 uM) or thioredoxin (up to 200 uM)

Formula: C32H34Cl3F2N3O2

CB-6644 - CAS# 2316817-88-4 BI-98782 Molecular Weight: 484CB 6644 is a novel allosteric selective inhibitor of the ruvbl1 2 complex with anti cancer activity. CB 6644 blocks the ATPase activity of RUVBL1 2 with an IC50 of 15 nM. CB 6644 interacts specifically with RUVBL1 2 in cancer cells, leading to cell death. Importantly, drug acquired resistant cell clones have amino acid mutations in either RUVBL1 or RUVBL2, suggesting that cell killing is an on target consequence of RUVBL1 2 engagement. In xenograft